Pathogens, Free Full-Text

Mycobacterium tuberculosis (Mtb) is a deadly pathogen and causative agent of human tuberculosis, causing ~1.5 million deaths every year. The increasing drug resistance of this pathogen necessitates novel and improved treatment strategies. A crucial aspect of the host–pathogen interaction is bacterial nutrition. In this study, Artemisia annua and Artemisia afra dichloromethane extracts were tested for bactericidal activity against Mtb strain mc26230 under hypoxia and various infection-associated carbon sources (glycerol, glucose, and cholesterol). Both extracts showed significant bactericidal activity against Mtb, regardless of carbon source. Based on killing curves, A. afra showed the most consistent bactericidal activity against Mtb for all tested carbon sources, whereas A. annua showed the highest bactericidal activity in 7H9 minimal media with glycerol. Both extracts retained their bactericidal activity against Mtb under hypoxic conditions. Further investigations are required to determine the mechanism of action of these extracts and identify their active constituent compounds.

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Melanins in fungal pathogens

Pathogens, Free Full-Text

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis - The Lancet

Pathogens, Free Full-Text, staphylococcus aureus

16.4: Pathogens - Biology LibreTexts

Pathogens An Open Access Journal from MDPI

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Pathogens and Disease - Wiley Online Library

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Pathogens Lesson - Bright in the Middle

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